AlzGPS
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Getting Started
Clinical Trials for Alzheimer's Disease
Drugs by First Level ATC Classification
Overview of the Datasets
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Node Legend
In MOA networks, neighbor genes that connect the same drug target-disease gene pairs are combined. Their sizes indicate the number of neighbor genes that are combined. For disease genes, their sizes indicate their distances to the drug targets.
In EGO networks, node size indicates brain expression specificity (see Getting Started - Methods).
Edge Legend
Protein-protein interaction
| Protein A | Protein B | Interaction Evidence Type |
|---|
Gene
| Symbol | |
| Name | |
| Type | |
| Chromosome | |
| Synonym | |
Target byNumber of known drugs that can target this gene |
is a known target of drug |
| Expression Score | is differentially expressed in of the 84 expression datasets |
| Genetic Evidence |
has genetic record |
Tissue SpecificitySource: GTEx v8 |
|
Brain Region SpecificitySource: GTEx v8 |
|
| Detail | Target by Dataset Variant Metabolite |
| External Link |
Clinical Trial
| Title | |
| Phase | |
| Status | |
| Sponsor | |
| Timeline |
First posted Last updated Start date Completion date Results first posted |
| Result | |
| Agent | |
| Mechanism |
Agent mechanism class Mechanism of action Therapeutic purpose Source |
| Link | ClinicalTrials.gov |
Drug
| Name | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Group | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ATC |
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| SMILES | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AD Clinical Trial |
has clinical trial |
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TargetNumber of known targets based on physical drug-target interaction |
has known target |
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| Proximity Score |
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| Literature Evidence | We found literature evidence | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Detail | Clinical Trial Target Proximity Literature | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Predicted ADMET Properties |
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| External Link |
Dataset
| ID | |
| Name | |
| Organism | |
| Ome-Type | |
| Method | |
| Genetic Background | |
| Model | |
| Age | |
| Region | |
| Cell Type | |
| Group | |
| Criteria | |
| Genes | |
| Source | |
| Note | |
| Detail | Genes Proximity |
| Organism | |
| Ome-Type | |
| Method | |
| Region | |
| Group | |
| Criteria | |
| Metabolites | |
| Source | |
| Note | |
| Detail | Metabolites |
| Genes | |
| Source | |
| Note | |
| Detail | Genes Proximity |
| External Link |
Variant
| ID | |||||||||||||||
| Mapped Genes |
|
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| External Link |
GWAS Catalog dbSNP |
Showing the top 50 drugs with the lowest z-scores
| Name | Proximity Score | Z | P | N | J | C | Open | MOA |
|---|---|---|---|---|---|---|---|---|
{name} |
{count_signp} |
- Expression dataset -
| ID | Organism | Ome-type | Method | Log2FC | FDR | Open |
|---|---|---|---|---|---|---|
| {id} | {taxon} | {omics} | {method} |
- Various dataset -
| ID | Name | Source | Open |
|---|---|---|---|
| {id} | {desc} | {source} |