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AlzGPS Network-based multi-omics analysis informs Alzheimer's patient care and therapeutic development

Contact us

Yadi Zhou

Developer
Data Scientist, PhD
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic
zhouy@ccf.org

Jiansong Fang

Research Scholar, PhD
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic
fangj3@ccf.org

Feixiong Cheng

Principal Investigator, PhD
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic
chengf@ccf.org
Phone: (216) 444-7654
https://www.lerner.ccf.org/gmi/cheng/

References

Harnessing Endophenotypes and Using Network Medicine in Alzheimer's Drug Repurposing Fang J, Pieper AA, Bekris L, Lee G, Nussinov R, Leverenz J, Cummings J, Cheng F Medicinal Research Reviews. 2020;40(6):2386-2426. PubMed | PMC

Endophenotype-based Discovery and Population-based Validation of Sildenafil in Reducing the Incidence of Alzheimer’s Disease Fang J, Zhang P, Zhou Y, Hou Y, Chiang WC, Stauffer S, Pieper AA, Li L, Cummings J, Cheng F 2020

Network-based Catalyzing Translation of GWAS Findings to Pathobiology and Therapeutics in Alzheimer's Disease Fang J, Zhang P, Wang Q, Zhou Y, Chiang WC, Chen R, Zhang B, Li B, Lewis JS, Pieper AA, Li L, Cummings J, Cheng F 2020 Medrxiv

A genome-wide positioning systems network algorithm for in silico drug repurposing Cheng F, Lu W, Liu C, Fang J, Hou Y, Handy D, Wang R, Zhao Y, Yang Y, Huang J, Hill D, Vidal M, Eng C, Loscalzo J Nat Commun. 2019;10:3476. PubMed | PMC

Alzheimer's disease drug development pipeline: 2020 Cummings J, Lee G, Ritter A, Sabbagh M, Zhong K Alzheimers Dement (N Y). 2020;6:e12050. PubMed | PMC

Alzheimer's disease drug development pipeline: 2019 Cummings J, Lee G, Ritter A, Sabbagh M, Zhong K Alzheimers Dement (N Y). 2019;5:272-293. PubMed | PMC

Alzheimer's disease drug development pipeline: 2018 Cummings J, Lee G, Ritter A, Zhong K Alzheimers Dement (N Y). 2018;4:195-214. PubMed | PMC